Great forest spiders rarely attack unprovoked, and often don't see people as a threat. Some spiders are passive enough to let people get close enough to pet them. When a great forest spider is attacked, they will defend their lives with full force, often requiring groups of 15-20 well-trained individuals to successfully take one down.
Great forest spiders have very few predators, but are often hunted by humans, mutants and ghouls. Killing a great forest spider is seen as a great feat in primitive or hunting-oriented cultures.